Fluindione-induced immuno-allergic interstitial nephritis

Fluindione-induced immuno-allergic interstitial nephritis

Drug-induced acute interstitial nephritis (AIN) is an established cause of acute kidney injury (AKI). Antibiotics and non-steroidal anti-inflammatory drugs (NSAIDs) are the most frequent offending drugs [1]. Only a few vitamin K antagonist-induced AIN cases have been reported. Some publications describe AIN associated with fluindione (Previscan R ©), an anticoagulant of the antivitamin K family...

Reversible Fluindione-Induced Chronic Interstitial Nephritis

Fluindione is well known to induce acute drug-induced interstitial nephritis (IN). Most cases occurred soon after the onset of treatment. We report a unique case of severe subacute fluindione-induced IN diagnosed 2 years after the treatment was begun. Renal function dramatically improved after fluindione withdrawal and steroid therapy.

Immuno-allergic interstitial nephritis related to fluindione: first biopsy proven cases.

Case 1. A 72-year-old man was admitted to our unit for acute renal failure (serum creatinine 353 mmol/l vs 107mmol/l at baseline). He had started fluindione for atrial fibrillation five weeks before. Clinical examination was normal. There was no eosinophilia. Urine protein/creatinine ratio was 25mg/mmol, containing low molecular weight protein without albumin. There was no haematuria or pyuria....

Ciprofloxacin-induced allergic interstitial nephritis.

Mesalazine induced interstitial nephritis.

5-Aminosalicylic acid (5-ASA) has structural similarities to both phenacetin and aspirin, which are known to cause 'analgesic nephropathy'. Because of the increasing use of 5-ASA, this paper draws attention to two cases of severe interstitial nephritis resulting from 5-ASA and emphasises the importance of monitoring renal functions of patients with inflammatory bowel diseases who are receiving ...